Most studied single cell

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Cell biochemistry studied by single-molecule imaging.

Over the last decade, there have been remarkable developments in live-cell imaging. We can now readily observe individual protein molecules within living cells and this should contribute to a systems level understanding of biological pathways. Direct observation of single fluorophores enables several types of molecular information to be gathered. Temporal and spatial trajectories enable diffusi...

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Single-Cell Migration as Studied by Scanning Electrochemical Microscopy.

Scanning electrochemical microscopy (SECM) was used to study the migration of single live head and neck cancer cells (SCC25). The newly developed graphite paste ultramicroelectrode (UME) showed significantly less fouling in comparison to a 10 μm Pt-UME and thus could be used to monitor and track the migration pattern of a single cell. We also used SECM probe scan curves to measure the morpholog...

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S studied via single neutron knockout reactions

R. R. Reynolds,1 P. D. Cottle,1 A. Gade,2,3 D. Bazin,2,3 C. M. Campbell,2,3 J. M. Cook,2,3 T. Glasmacher,2,3 P. G. Hansen,2,3 T. Hoagland,2 K. W. Kemper,1 W. F. Mueller,2 B. T. Roeder,1 J. R. Terry,2,3 and J. A. Tostevin4 1Physics Department, Florida State University, Tallahassee, Florida 32306, USA 2National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, Michiga...

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Single Molecule Dynamics Studied by Polarization Modulation.

We observed and made unambiguous distinctions between abrupt photophysical events of single molecules: a rotational jump of a single dipole, a transition to a dark state (reversible and irreversible photobleaching), and a spectral jump. The study was performed in the far field by modulating the excitation polarization and monitoring the fluorescence in time. This technique also allowed us to me...

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Cephalic tetanus studied with single fibre EMG.

In a case of cephalic tetanus with left facial spasms and trismus, the repetitive stimulation of the left facial nerve at 3, 10 and 20 Hz showed no facilitation or decrement. The amplitudes of the blink reflex were 50% lower on the affected side. The silent period of the masseter muscles was shortened. Concentric needle examination of the masseters and left facial EMG of the left frontalis musc...

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ژورنال

عنوان ژورنال: Nature

سال: 1976

ISSN: 0028-0836,1476-4687

DOI: 10.1038/260467a0